EPIDEMIOLOGY AND HEALTH DATA INSIGHTS
Review Article

Endocrine-Disrupting Chemicals in Personal Care Products: Exposure Pathways and Health Effects

Epidemiology and Health Data Insights, 2(4), 2026, ehdi040, https://doi.org/10.63946/ehdi/18537
Publication date: May 08, 2026
Full Text (PDF)

ABSTRACT

Endocrine-disrupting chemicals (EDCs) are exogenous substances that interfere with the normal functioning of the endocrine system, leading to adverse effects on human health, particularly in relation to reproductive, developmental, and metabolic processes. Recent research has increasingly identified personal care products (PCPs) as a major source of EDC exposure. These often contain chemicals such as parabens, phthalates, and triclosan, which retain endocrine activity even at low concentrations. 
This narrative review aimed to consolidate current research on the exposure pathways, health effects, and regulatory frameworks associated with EDCs in PCPs.  
A narrative review approach was adopted, focusing on studies published between 2021 and 2026. A comprehensive literature search was conducted in PubMed and ScienceDirect. 
The review found that EDCs are widely present in personal care products and dermal absorption, oral ingestion, and inhalation are the primary pathways through which EDCs enter the body.  EDCs pose significant risks to human health, including reproductive dysfunction, developmental delays, metabolic disorders, and cancer risks with cumulative exposure exacerbating these risks. Regulatory frameworks vary globally, with many regions lagging in addressing the long-term impacts of EDC exposure.
Ultimately, the findings emphasize the urgent need to address the public health implications of EDC exposure from PCPs, which contribute to chronic diseases across multiple systems. Effective policy recommendations include stricter regulations on EDCs in consumer products, better monitoring systems, and enhanced consumer awareness. These findings will be of significant value to public health officials, regulatory bodies, industry stakeholders, and health professionals who can influence and implement strategies for reducing EDC exposure to protect human health.

KEYWORDS

Endocrine-Disrupting Chemicals Personal Care Products Exposure Pathways Health Effects Regulatory Frameworks

CITATION (Vancouver)

Okeoma OI, Adeoba MI, Nwokedi VU. Endocrine-Disrupting Chemicals in Personal Care Products: Exposure Pathways and Health Effects. Epidemiology and Health Data Insights. 2026;2(4):ehdi040. https://doi.org/10.63946/ehdi/18537
APA
Okeoma, O. I., Adeoba, M. I., & Nwokedi, V. U. (2026). Endocrine-Disrupting Chemicals in Personal Care Products: Exposure Pathways and Health Effects. Epidemiology and Health Data Insights, 2(4), ehdi040. https://doi.org/10.63946/ehdi/18537
Harvard
Okeoma, O. I., Adeoba, M. I., and Nwokedi, V. U. (2026). Endocrine-Disrupting Chemicals in Personal Care Products: Exposure Pathways and Health Effects. Epidemiology and Health Data Insights, 2(4), ehdi040. https://doi.org/10.63946/ehdi/18537
AMA
Okeoma OI, Adeoba MI, Nwokedi VU. Endocrine-Disrupting Chemicals in Personal Care Products: Exposure Pathways and Health Effects. Epidemiology and Health Data Insights. 2026;2(4), ehdi040. https://doi.org/10.63946/ehdi/18537
Chicago
Okeoma, Obiageri Ihuarulam, Mariam Iyabo Adeoba, and Vivian Ukamaka Nwokedi. "Endocrine-Disrupting Chemicals in Personal Care Products: Exposure Pathways and Health Effects". Epidemiology and Health Data Insights 2026 2 no. 4 (2026): ehdi040. https://doi.org/10.63946/ehdi/18537
MLA
Okeoma, Obiageri Ihuarulam et al. "Endocrine-Disrupting Chemicals in Personal Care Products: Exposure Pathways and Health Effects". Epidemiology and Health Data Insights, vol. 2, no. 4, 2026, ehdi040. https://doi.org/10.63946/ehdi/18537

REFERENCES

  1. Boronow KE, Brody JG. What do people need to know about endocrine disrupting chemicals and health? A mental models approach using focus groups of community-engaged research teams and a national survey. BMC Public Health. 2025 Nov 22;25(1):4414. doi:10.1186/s12889-025-25561-4
  2. Kalofiri P, Biskanaki F, Kefala V, Tertipi N, Sfyri E, Rallis E. Endocrine Disruptors in Cosmetic Products and the Regulatory Framework: Public Health Implications. Cosmetics. 2023 Dec;10(6):160. doi:10.3390/cosmetics10060160
  3. Kalsi Rajashekara N, Natarajan M, Srinivasan A, Babu J, Madhunapantula SV, Jayshankar B, et al. Role of personal care products as endocrine disruptors affecting reproductive age women. Front Reprod Health. 2025 Jul 11;7. doi:10.3389/frph.2025.1514060
  4. Alblooshi S. The impact of perfumes and cosmetic products on human health: a narrative review. Front Toxicol. 2025 Aug 29;7. doi:10.3389/ftox.2025.1646075
  5. Waits A, Chang CH, Huang YF, Tsai MS, Hou JW, Wang PW, et al. Socioeconomic status in the association between use of personal care products and exposure to endocrine-disrupting chemicals in pregnant Taiwanese women. Front Public Health. 2025 Apr 10;13. doi:10.3389/fpubh.2025.1537669
  6. de Paula LCP, Alves C. Food packaging and endocrine disruptors. Jornal de Pediatria. 2024 Mar 1;100:S40–7. doi:10.1016/j.jped.2023.09.010
  7. Perkins T. Kids using lotions have higher levels of hormone-disrupting toxins – study. The Guardian [Internet]. 2024 Sep 14 [cited 2025 Dec 23]. Available from: https://www.theguardian.com/environment/2024/sep/14/kids-sunscreen-lotions-phthalates-study
  8. European Commission. Endocrine disruptors - Internal Market, Industry, Entrepreneurship and SMEs [Internet]. [cited 2025 Dec 23]. Available from: https://single-market-economy.ec.europa.eu/sectors/cosmetics/cosmetic-products-specific-topics/endocrine-disruptors_en
  9. Holmer ML, Holmberg RD, Despicht C, Bouftas N, Axelstad M, Beronius A, et al. Assessment of endocrine disruptors in the European Union: Current regulatory framework, use of new approach methodologies (NAMs) and recommendations for improvements. Regulatory Toxicology and Pharmacology. 2025 Nov 1;162:105883. doi:10.1016/j.yrtph.2025.105883
  10. Environmental Working Group (EWG). Personal care product chemicals banned in Europe but still found in the U.S. | Environmental Working Group [Internet]. 2022 [cited 2025 Dec 23]. Available from: https://www.ewg.org/news-insights/news/2022/10/personal-care-product-chemicals-banned-europe-still-found-us
  11. Reda Wigle. 6 chemicals allowed in US cosmetics but banned in the EU, UK [Internet]. 2025 [cited 2025 Dec 23]. Available from: https://nypost.com/2025/09/15/health/6-chemicals-allowed-in-us-cosmetics-but-banned-in-the-eu-uk/
  12. Onyebuchi C, Muogbo I, Chukwurah CO, Abdulkadir M, Gordon OP, Ogundare SA, et al. Endocrine Disrupting Chemicals and Health in Europe: A Systematic Review and Meta-Analysis. medtigo Journal of Pharmacology. 2025 Aug 20;2(3). doi:10.63096/medtigo30612310
  13. James OE, Abah MA, Oladosu MA, Agida OD, Tatah V, EneOjo EA. Human Exposure to Endocrine-Disrupting Chemicals: A Review of Sources, Health Effects, and Biomonitoring Strategies - Journal of e-Science Letters [Internet]. 2025 Dec 25 [cited 2025 Dec 23]. Available from: https://scienceletters.researchfloor.org/human-exposure-to-endocrine-disrupting-chemicals-a-review-of-sources-health-effects-and-biomonitoring-strategies/
  14. Agarwal S, Charlesworth M, Elrakhawy M. How to write a narrative review. Anaesthesia. 2023 Sep;78(9):1162–6. doi:10.1111/anae.16016
  15. Leblanc V, Hamroun A, Bentegeac R, Le Guellec B, Lenain R, Chazard E. Added Value of Medical Subject Headings Terms in Search Strategies of Systematic Reviews: Comparative Study. J Med Internet Res. 2024 Nov 19;26:e53781. doi:10.2196/53781
  16. Bramer WM, de Jonge GB, Rethlefsen ML, Mast F, Kleijnen J. A systematic approach to searching: an efficient and complete method to develop literature searches. J Med Libr Assoc. 2018 Oct;106(4):531–41. doi:10.5195/jmla.2018.283
  17. Darbre PD. Endocrine disruption. In: Personal Care Products and Human Health [Internet]. Academic Press; 2023 [cited 2026 Jan 3]. p. 231–66. Available from: https://www.sciencedirect.com/science/chapter/edited-volume/abs/pii/B9780323996846000112 doi:10.1016/B978-0-323-99684-6.00011-2
  18. Li Y, Zheng N, Sun S, Wang S, Li X, Pan J, et al. Exposure estimates of parabens from personal care products compared with biomonitoring data in human hair from Northeast China. Ecotoxicology and Environmental Safety. 2023 Nov 15;267:115635. doi:10.1016/j.ecoenv.2023.115635
  19. Rivera-Núñez Z, Kinkade CW, Zhang Y, Rockson A, Bandera EV, Llanos AAM, et al. Phenols, Parabens, Phthalates and Puberty: a Systematic Review of Synthetic Chemicals Commonly Found in Personal Care Products and Girls’ Pubertal Development. Curr Environ Health Rep. 2022 Dec;9(4):517–34. doi:10.1007/s40572-022-00366-4
  20. Sharma D, Sinha R, Multisanti CR, Faggio C. From personal hygiene products to health threats: Triclosan and its impact on endocrine health. Sci Total Environ. 2025 Dec 1;1006:180856. doi:10.1016/j.scitotenv.2025.180856
  21. Tomar C, Singh P, Yadav S. Endocrine-disrupting chemicals in cosmetics: mechanistic insights and their impact on human and skin health. Rev Endocr Metab Disord. 2025 Nov 27. doi:10.1007/s11154-025-10006-5
  22. Johnson PI, Favela K, Jarin J, Le AM, Clark PY, Fu L, et al. Chemicals of concern in personal care products used by women of color in three communities of California. J Expo Sci Environ Epidemiol. 2022;32(6):864–76. doi:10.1038/s41370-022-00485-y
  23. Darbre PD, Harvey PW. Regulatory Considerations for Dermal Application of Endocrine Disrupters in Personal Care Products. In: Endocrine Disruption and Human Health [Internet]. Academic Press; 2022 [cited 2026 Jan 3]. p. 463–84. Available from: https://www.sciencedirect.com/science/chapter/edited-volume/abs/pii/B9780128219850000220 doi:10.1016/B978-0-12-821985-0.00022-0
  24. Chen J, Song P, Li C, Liu H, Zhang L, Zhou Y, et al. Endocrine disrupting chemicals exposure and health: An umbrella review. Ecotoxicol Environ Saf. 2025 Sep 1;302:118574. doi:10.1016/j.ecoenv.2025.118574
  25. Del Río Barrera T, Zambrano Ledesma KN, Aguilar Hernández M, Reyes Chávez K, Aguirre Barajas AF, Alvarez Vázquez DP, et al. Endocrine Disruptors and Their Impact on Quality of Life: A Literature Review. Cureus. 2025 May;17(5):e83890. doi:10.7759/cureus.83890
  26. Kumar M, Sarma DK, Shubham S, Kumawat M, Verma V, Prakash A, et al. Environmental Endocrine-Disrupting Chemical Exposure: Role in Non-Communicable Diseases. Front Public Health. 2020 Sep 24;8. doi:10.3389/fpubh.2020.553850
  27. Tzouma Z, Dourou P, Diamanti A, Harizopoulou V, Papalexis P, Karampas G, et al. Associations Between Endocrine-Disrupting Chemical Exposure and Fertility Outcomes: A Decade of Human Epidemiological Evidence. Life. 2025 Jul;15(7):993. doi:10.3390/life15070993
  28. Ghosh A, Tripathy A, Ghosh D. Impact of Endocrine Disrupting Chemicals (EDCs) on Reproductive Health of Humans. Proc Zool Soc. 2022 Mar 1;75(1):16–30. doi:10.1007/s12595-021-00412-3
  29. Yan Y, Guo F, Liu K, Ding R, Wang Y. The effect of endocrine-disrupting chemicals on placental development. Front Endocrinol (Lausanne). 2023 Feb 21;14:1059854. doi:10.3389/fendo.2023.1059854
  30. Kahn LG, Philippat C, Nakayama SF, Slama R, Trasande L. Endocrine-disrupting chemicals: implications for human health. Lancet Diabetes Endocrinol. 2020 Aug;8(8):703–18. doi:10.1016/S2213-8587(20)30129-7
  31. Yue B, Ning S, Miao H, Fang C, Li J, Zhang L, et al. Human exposure to a mixture of endocrine disruptors and serum levels of thyroid hormones: A cross-sectional study. J Environ Sci (China). 2023 Mar;125:641–9. doi:10.1016/j.jes.2022.01.017
  32. Zeng B, Wu Y, Huang Y, Colucci M, Bancaro N, Maddalena M, et al. Carcinogenic health outcomes associated with endocrine disrupting chemicals exposure in humans: A wide-scope analysis. Journal of Hazardous Materials. 2024 Sep 5;476:135067. doi:10.1016/j.jhazmat.2024.135067
  33. Alsen M, Sinclair C, Cooke P, Ziadkhanpour K, Genden E, van Gerwen M. Endocrine Disrupting Chemicals and Thyroid Cancer: An Overview. Toxics. 2021 Jan;9(1):14. doi:10.3390/toxics9010014
  34. Buoso E, Masi M, Racchi M, Corsini E. Endocrine-Disrupting Chemicals’ (EDCs) Effects on Tumour Microenvironment and Cancer Progression: Emerging Contribution of RACK1. Int J Mol Sci. 2020 Dec 3;21(23):9229. doi:10.3390/ijms21239229
  35. Pei Z, Zhang L, Bao Y, Li J, Zhuo Q. The negative impacts of bisphenols on thyroid function in adults with bisphenol A exposure level exceeding the tolerable daily intake. Ecotoxicology and Environmental Safety. 2025 Jan 15;290:117790. doi:10.1016/j.ecoenv.2025.117790
  36. Ahn C, Jeung EB. Endocrine-Disrupting Chemicals and Disease Endpoints. International Journal of Molecular Sciences. 2023 Jan;24(6):5342. doi:10.3390/ijms24065342
  37. Pravednikov A, Perkovic S, Lagerkvist CJ. Main factors influencing the perceived health risk of endocrine-disrupting chemicals: A systematic literature review. Environmental Research. 2024 Dec 1;262:119836. doi:10.1016/j.envres.2024.119836
  38. Preston EV, Chan M, Nozhenko K, Bellavia A, Grenon MC, Cantonwine DE, et al. Socioeconomic and racial/ethnic differences in use of endocrine-disrupting chemical-associated personal care product categories among pregnant women. Environ Res. 2021 Jul;198:111212. doi:10.1016/j.envres.2021.111212
  39. Nnamani EA, Bayode AA, Otitoju OB, Alfred MO, Omorogie MO. Environmental profiling of endocrine disrupting chemicals in ground water sources: an African perspective. RSC Adv. 2025 Jul 25;15(33):26673–92. doi:10.1039/D5RA04114G
  40. Ngeno E, Ongulu R, Orata F, Matovu H, Shikuku V, Onchiri R, et al. Endocrine disrupting chemicals in wastewater treatment plants in Kenya, East Africa: Concentrations, removal efficiency, mass loading rates and ecological impacts. Environmental Research. 2023 Nov 15;237:117076. doi:10.1016/j.envres.2023.117076
  41. Kanakaraju D, Glass BD, Goh PS. Advanced oxidation process-mediated removal of pharmaceuticals from water: a review of recent advances. Environmental Science and Pollution Research International. 2025 May 28;32(24):14316. doi:10.1007/s11356-025-36547-5
  42. Antony S, Antony S, Rebello S, George S, Biju DT, R R, et al. Bioremediation of Endocrine Disrupting Chemicals- Advancements and Challenges. Environmental Research. 2022 Oct 1;213:113509. doi:10.1016/j.envres.2022.113509
  43. European Union. Regulation (EC) No 1223/2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products (recast) (Text with EEA relevance) (c. 1223) [Internet]. 2009 [cited 2026 Jan 3]. Available from: https://www.legislation.gov.uk/eur/2009/1223/2009-11-30/data.xht?view=snippet&wrap=true
  44. Alaranta J, Miettinen M. Precautiously Circular: Perspectives on the Application of the Precautionary Principle in European Union Waste and Chemicals Regulation. European Journal of Risk Regulation. 2023 Mar;14(1):14–30. doi:10.1017/err.2022.37
  45. Environmental Protection Agency (EPA). Federal Register [Internet]. 2025 [cited 2026 Jan 3]. Procedures for Chemical Risk Evaluation Under the Toxic Substances Control Act (TSCA). Available from: https://www.federalregister.gov/documents/2025/09/23/2025-18431/procedures-for-chemical-risk-evaluation-under-the-toxic-substances-control-act-tsca
  46. Barton-Maclaren TS, Wade M, Basu N, Bayen S, Grundy J, Marlatt V, et al. Innovation in regulatory approaches for endocrine disrupting chemicals: The journey to risk assessment modernization in Canada. Environ Res. 2022 Mar;204(Pt C):112225. doi:10.1016/j.envres.2021.112225
  47. Ho V, Pelland-St-Pierre L, Gravel S, Bouchard MF, Verner MA, Labrèche F. Endocrine disruptors: Challenges and future directions in epidemiologic research. Environmental Research. 2022 Mar 1;204:111969. doi:10.1016/j.envres.2021.111969
  48. Jaskulak M, Zimowska M, Rolbiecka M, Zorena K. Understanding the role of endocrine disrupting chemicals as environmental obesogens in the obesity epidemic: A comprehensive overview of epidemiological studies between 2014 and 2024. Ecotoxicology and Environmental Safety. 2025 Jul 1;299:118401. doi:10.1016/j.ecoenv.2025.118401
  49. Qu R, Wang J, Li X, Zhang Y, Yin T, Yang P. Per- and Polyfluoroalkyl Substances (PFAS) Affect Female Reproductive Health: Epidemiological Evidence and Underlying Mechanisms. Toxics. 2024 Sep 18;12(9):678. doi:10.3390/toxics12090678
  50. Weiss MC, Wang L, Sargis RM. Hormonal Injustice: Environmental Toxicants as Drivers of Endocrine Health Disparities. Endocrinol Metab Clin North Am. 2023 Dec;52(4):719–36. doi:10.1016/j.ecl.2023.05.009
  51. Corbett GA, Lee S, Woodruff TJ, Hanson M, Hod M, Charlesworth AM, et al. Nutritional interventions to ameliorate the effect of endocrine disruptors on human reproductive health: A semi-structured review from FIGO. Int J Gynaecol Obstet. 2022 Jun;157(3):489–501. doi:10.1002/ijgo.14126
  52. Hilz EN, Gore AC. Endocrine-Disrupting Chemicals: Science and Policy. Policy Insights Behav Brain Sci. 2023 Oct;10(2):142–50. doi:10.1177/23727322231196794
  53. Kassotis CD, Vandenberg LN, Demeneix BA, Porta M, Slama R, Trasande L. Endocrine-disrupting chemicals: economic, regulatory, and policy implications. The Lancet Diabetes & Endocrinology. 2020 Aug 1;8(8):719–30. doi:10.1016/S2213-8587(20)30128-5

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