EPIDEMIOLOGY AND HEALTH DATA INSIGHTS
Review Article
May 18, 2026 15 8

Digital Mental Health Interventions for Depression and Anxiety in Youth: A Scoping Review of Effectiveness, Engagement, and Implementation

Heidi Heather Henry 1 * ,
Anthony Onyebuchi Onwudiwe 2,
Susan Ayobami Ogundare 3,
Daniel Obinna Eke 1
1 Department of Nursing, Myrtle E. and Earl E. Walker College of Health Professions Maryville University of St. Louis, St. Louis, MO, USA2 Department of Psychology, Faculty of Social Sciences, Chukwuemeka Odumegwu Ojukwu University, Igbariam, Anambra State, Nigeria3 Department of Medicine, Lautech, College of Health Sciences, Ogbomoso, Oyo State, Nigeria* Corresponding Author
Epidemiology and Health Data Insights, 2(4), 2026, ehdi041, https://doi.org/10.63946/ehdi/18571
Publication date: May 18, 2026
Full Text (PDF)

ABSTRACT

Depression and anxiety are among the most prevalent mental health conditions affecting children, adolescents, and young people, contributing substantially to the global burden of disease. Despite the availability of effective treatments, access to care remains limited due to structural, economic, and stigma-related barriers, particularly in low-resource settings. Digital mental health interventions have emerged as a scalable and accessible approach to addressing these gaps. This scoping review aimed to map the extent, range, and characteristics of existing evidence on digital interventions targeting depression and anxiety in individuals aged approximately 10–24 years, with a focus on effectiveness, engagement, and implementation. A systematic search of PubMed, Dimensions, and CINAHL was conducted, and primary studies of any design published in English were included. Data were extracted and synthesized using descriptive and thematic approaches. A total of 42 studies were included, covering diverse modalities such as internet-based cognitive behavioral therapy, mobile applications, chatbots, and tele-mental health platforms. Digital interventions were associated with reductions in depressive and anxiety symptoms, particularly in the short term. However, between-group effects were often modest when compared with active controls. Engagement emerged as a key determinant of effectiveness, with higher adherence linked to better outcomes. While feasibility and acceptability were generally high, challenges related to sustained engagement and long-term effectiveness were common. Digital interventions show promise as adjuncts to conventional care but require further optimization and evaluation in real-world settings.

KEYWORDS

Digital Mental Health Depression Anxiety Youth Digital Interventions Engagement Scoping Review

CITATION (Vancouver)

Henry HH, Onwudiwe AO, Ogundare SA, Eke DO. Digital Mental Health Interventions for Depression and Anxiety in Youth: A Scoping Review of Effectiveness, Engagement, and Implementation. Epidemiology and Health Data Insights. 2026;2(4):ehdi041. https://doi.org/10.63946/ehdi/18571
APA
Henry, H. H., Onwudiwe, A. O., Ogundare, S. A., & Eke, D. O. (2026). Digital Mental Health Interventions for Depression and Anxiety in Youth: A Scoping Review of Effectiveness, Engagement, and Implementation. Epidemiology and Health Data Insights, 2(4), ehdi041. https://doi.org/10.63946/ehdi/18571
Harvard
Henry, H. H., Onwudiwe, A. O., Ogundare, S. A., and Eke, D. O. (2026). Digital Mental Health Interventions for Depression and Anxiety in Youth: A Scoping Review of Effectiveness, Engagement, and Implementation. Epidemiology and Health Data Insights, 2(4), ehdi041. https://doi.org/10.63946/ehdi/18571
AMA
Henry HH, Onwudiwe AO, Ogundare SA, Eke DO. Digital Mental Health Interventions for Depression and Anxiety in Youth: A Scoping Review of Effectiveness, Engagement, and Implementation. Epidemiology and Health Data Insights. 2026;2(4), ehdi041. https://doi.org/10.63946/ehdi/18571
Chicago
Henry, Heidi Heather, Anthony Onyebuchi Onwudiwe, Susan Ayobami Ogundare, and Daniel Obinna Eke. "Digital Mental Health Interventions for Depression and Anxiety in Youth: A Scoping Review of Effectiveness, Engagement, and Implementation". Epidemiology and Health Data Insights 2026 2 no. 4 (2026): ehdi041. https://doi.org/10.63946/ehdi/18571
MLA
Henry, Heidi Heather et al. "Digital Mental Health Interventions for Depression and Anxiety in Youth: A Scoping Review of Effectiveness, Engagement, and Implementation". Epidemiology and Health Data Insights, vol. 2, no. 4, 2026, ehdi041. https://doi.org/10.63946/ehdi/18571

REFERENCES

  1. Lattie EG, Adkins EC, Winquist N, Stiles-Shields C, Wafford QE, Graham AK. Digital mental health interventions for depression, anxiety, and enhancement of psychological well-being among college students: systematic review. J Med Internet Res. 2019;21(7):e12869. doi:10.2196/12869
  2. Atewologun F, Adigun OA, Okesanya OJ, et al. A comprehensive review of mental health services across selected countries in sub-Saharan Africa: assessing progress, challenges, and future direction. Discov Ment Health. 2025;5:49. doi:10.1007/s44192-025-00177-7
  3. Adjei-Boateng D, Ikoh CL. Digital mental health interventions for adolescents and young people: evaluating efficacy and accessibility. Cureus. 2025;17(6):e85943. doi:10.7759/cureus.85943
  4. Al Dweik R, Ajaj R, Kotb R, et al. Opportunities and challenges in leveraging digital technology for mental health system strengthening: a systematic review. BMC Public Health. 2024;24:2592. doi:10.1186/s12889-024-19980-y
  5. Löchner J, Carlbring P, Schuller B, Torous J, Sander LB. Digital interventions in mental health: an overview and future perspectives. Internet Interv. 2025;40:100824. doi:10.1016/j.invent.2025.100824
  6. Torous J, Linardon J, Goldberg SB, Sun S, Bell I, Nicholas J, et al. The evolving field of digital mental health: current evidence and implementation issues. World Psychiatry. 2025;24(2):156–174. doi:10.1002/wps.21299
  7. Hong SH, Chun TK, Nam YJ, Kim TW, Cho YH, Son SJ, et al. Digital mental health interventions for adolescents: an integrative review. Children (Basel). 2025;12(6):770. doi:10.3390/children12060770
  8. Asselbergs J, Ruwaard J, Ejdys M, Schrader N, Sijbrandij M, Riper H. Mobile phone-based unobtrusive ecological momentary assessment of day-to-day mood. J Med Internet Res. 2016;18(3):e72. doi:10.2196/jmir.5505
  9. Bell IH, Nicholas J, Alvarez-Jimenez M, Thompson A, Gleeson J. Digital interventions for youth mental health: randomized controlled trial. J Med Internet Res. 2023. doi:10.2196/47860
  10. Carey TA, Haviland J, Tai SJ, Vanags T, Mansell W. MindSurf: a pilot study of a smartphone app for mental health. JMIR Ment Health. 2016. doi:10.1186/s12888-016-1168-z
  11. Casella CB, Zuccolo PF, Sugaya L, de Souza AS, Otoch L, Alarcão F, et al. Internet-delivered CBT for youth during COVID-19: protocol. Trials. 2022;23:899. doi:10.1186/s13063-022-06836-2
  12. Creswell C, Taylor L, Giles S, Howitt S, Radley L, Whitaker E, et al. Digitally augmented CBT versus treatment as usual for child anxiety. Lancet Psychiatry. 2024;11(3):193–209. doi:10.1016/S2215-0366(23)00429-7
  13. Stout DM, Acheson DT, Moore TM, Gur RC, Baker DG, Geyer MA, et al. Individual variation in working memory is associated with fear extinction performance. Behav Res Ther. 2018;102:52–59.
  14. Deady M, Mills KL, Teesson M, Kay-Lambkin F. A web-based intervention for co-occurring depression and problematic alcohol use in young people: randomized controlled trial. J Med Internet Res. 2016;18(3):e71. doi:10.2196/jmir.5178
  15. Elzinga E, de Beurs D, Beekman ATF, Berkelmans G, Gilissen R. Who didn’t consult the doctor? Understanding sociodemographic factors in relation to health care uptake before suicide. J Affect Disord. 2021;287:158–164. doi:10.1016/j.jad.2021.03.035
  16. Senyard EL, Rowe A, Krishnamoorthy G, Spence SH, Donovan C, March S. Early engagement in a digital mental health intervention for adolescent anxiety. JMIR Pediatr Parent. 2025;8:e60523. doi:10.2196/60523
  17. Fujita J, Yano Y, Shinoda S, Sho N, Otsuki M, Suda A, Takayama M, Moroga T, Yamaguchi H, Ishii M, Miyazaki T. Challenges in implementing a mobile AI chatbot intervention for depression among youth on psychiatric waiting lists: randomized controlled study termination report. JMIRx Med. 2025;6:e70960. doi:10.2196/70960
  18. Geirhos A, Domhardt M, Lunkenheimer F, Temming S, Holl RW, Minden K, Warschburger P, Meissner T, Mueller-Stierlin AS, Baumeister H. Feasibility and potential efficacy of a guided internet- and mobile-based CBT for adolescents and young adults with chronic medical conditions and comorbid depression or anxiety symptoms (youthCOACHCD): a randomized controlled pilot trial. BMC Pediatr. 2022;22(1):69. doi:10.1186/s12887-022-03134-3
  19. Rosso IM, Killgore WD, Olson EA, Webb CA, Fukunaga R, Auerbach RP, et al. Internet-based CBT for major depressive disorder. Depress Anxiety. 2017;34(3):236–245. doi:10.1002/da.22590
  20. Schleider JL, Mullarkey MC, Fox KR, Dobias ML, Shroff A, Hart EA, et al. Online single-session interventions for adolescent depression. Nat Hum Behav. 2022;6(2):258–268. doi:10.1038/s41562-021-01235-0
  21. Demirci JR, Bogen DL. Feasibility and acceptability of a mobile app in EMA of breastfeeding. Matern Child Nutr. 2017;13(3):e12342. doi:10.1111/mcn.12342
  22. Pachankis JE, Soulliard ZA, Layland EK, Behari K, Seager van Dyk I, Eisenstadt BE, et al. LGBTQ-affirmative internet-based CBT. Behav Res Ther. 2023;169:104403. doi:10.1016/j.brat.2023.104403
  23. Karkosz S, Szymański R, Sanna K, Michałowski J. Effectiveness of a web-based and mobile therapy chatbot on anxiety and depressive symptoms in subclinical young adults: randomized controlled trial. JMIR Form Res. 2024;8:e47960. doi:10.2196/47960
  24. Anderson K, Burford O, Emmerton L. Mobile health apps to facilitate self-care: a qualitative study. PLoS One. 2016;11(5):e0156164. doi:10.1371/journal.pone.0156164
  25. Kenter RM, Cuijpers P, Beekman ATF, van Straten A. Effectiveness of a web-based guided self-help intervention for outpatients with a depressive disorder: short-term results from a randomized controlled trial. J Med Internet Res. 2016;18(3):e80. doi:10.2196/jmir.4861
  26. King CA, Eisenberg D, Zheng K, Czyz EK, Kramer A, Horwitz A, Chermack S. Online suicide risk screening and intervention with college students: a pilot randomized controlled trial. J Consult Clin Psychol. 2015;83(3):630–636. doi:10.1037/a0038805
  27. Koziol-McLain J, Vandal AC, Nada-Raja S, et al. A web-based intervention for abused women: the New Zealand isafe randomised controlled trial protocol. BMC Public Health. 2015;15:56. doi:10.1186/s12889-015-1395-0
  28. Kulikov VN, Crosthwaite PC, Hall SA, Flannery JE, Strauss GS, Vierra EM, et al. A CBT-based mobile intervention for adolescents with depression: feasibility trial. Front Digit Health. 2023;5:1062471. doi:10.3389/fdgth.2023.1062471
  29. Lawrence-Sidebottom D, Huffman LG, Beam AB, McAlister K, Guerra R, Parikh A, Roots M, Huberty J. Using a digital mental health intervention for crisis support and mental health care among children and adolescents with self-injurious thoughts and behaviors: retrospective study. JMIR Form Res. 2024;8:e54816. doi:10.2196/54816
  30. Li G, Sit HF, Chen W, Wu K, Sou EKL, Wong M, et al. WHO digital intervention for depression among young adults. Transl Psychiatry. 2024;14:102. doi:10.1038/s41398-024-02700-0
  31. Litvin S, Saunders R, Jefferies P, Seely H, Pössel P, Lüttke S. The impact of a gamified mobile mental health app (eQuoo) on resilience and mental health in a student population: large-scale randomized controlled trial. JMIR Ment Health. 2023 Jul 21;10:e47285. doi:10.2196/47285
  32. Lunkenheimer F, Domhardt M, Geirhos A, Kilian R, Mueller-Stierlin AS, Holl RW, et al. Guided internet- and mobile-based CBT for youth: study protocol. Trials. 2020;21(1):253. doi:10.1186/s13063-019-4041-9
  33. Gleason MM, Flom M, Rapoport S, Williams A, Birch A, Wells NK, Forman-Hoffman V, Robinson A. A relational agent intervention for adolescents seeking mental health treatment: outcomes from a randomized controlled trial within a children's outpatient hospital. JAACAP Open. 2025 Feb 11;3(4):1033-45. doi:10.1016/j.jaacop.2025.02.002
  34. Maulik PK, Tewari A, Devarapalli S, Kallakuri S, Patel A. The systematic medical appraisal, referral and treatment (SMART) mental health project: development and testing of electronic decision support system and formative research to understand perceptions about mental health in rural India. PLoS One. 2016;11(10):e0164404. doi:10.1371/journal.pone.0164404
  35. Mueller C, Stollfuss B, Roitenberg A, Harder J, Richter MJ. Evaluation of clinical outcomes and simultaneous digital tracking of daily physical activity, heart rate, and inhalation behavior in patients with pulmonary arterial hypertension treated with inhaled iloprost: protocol for the observational VENTASTEP study. JMIR Res Protoc. 2019;8(4):e12144. doi:10.2196/12144
  36. Nicol G, Wang R, Graham S, Dodd S, Garbutt J. Chatbot-delivered cognitive behavioral therapy in adolescents with depression and anxiety during the COVID-19 pandemic: feasibility and acceptability study. JMIR Form Res. 2022;6(11):e40242. doi:10.2196/40242
  37. North F, Chaudhry R. Apple HealthKit and Health app: patient uptake and barriers in primary care. Telemed J E Health. 2016;22(7):608–613. doi:10.1089/tmj.2015.0106
  38. Peake E, Miller I, Flannery J, Chen L, Lake J, Padmanabhan A. Preliminary efficacy of a digital intervention for adolescent depression: randomized controlled trial. J Med Internet Res. 2024;26:e48467. doi:10.2196/48467
  39. Pots WT, Fledderus M, Meulenbeek PA, ten Klooster PM, Schreurs KM, Bohlmeijer ET. Acceptance and commitment therapy as a web-based intervention for depressive symptoms: randomised controlled trial. Br J Psychiatry. 2016;208(1):69–77. doi:10.1192/bjp.bp.114.146068
  40. Rickhi B, Kania-Richmond A, Moritz S, Cohen J, Paccagnan P, Dennis C, Liu M, Malhotra S, Steele P, Toews J. Evaluation of a spirituality informed e-mental health tool as an intervention for major depressive disorder in adolescents and young adults: a randomized controlled pilot trial. BMC Complement Altern Med. 2015;15:450. doi:10.1186/s12906-015-0968-x
  41. Ritvo P, Knyahnytska Y, Pirbaglou M, Wang W, Tomlinson G, Zhao H, Linklater R, Bai S, Kirk M, Katz J, Harber L, Daskalakis ZJ. Online mindfulness-based cognitive behavioral therapy intervention for youth with major depressive disorders: randomized controlled trial. J Med Internet Res. 2021;23(3):e24380. doi:10.2196/24380
  42. Schomerus G, Angermeyer MC, Baumeister SE, Stolzenburg S, Link BG, Phelan JC. An online intervention using information on the mental health–mental illness continuum to reduce stigma. Eur Psychiatry. 2016;32:21–27. doi:10.1016/j.eurpsy.2015.11.006
  43. Cross S, Liu P, Scott I, O’Sullivan S, Nicholas J, Valentine L, et al. Predicting clinical improvement in youth using digital intervention. Behav Res Ther. 2025;186:104703. doi:10.1016/j.brat.2025.104703
  44. Rice S, Gleeson J, Davey C, Hetrick S, Parker A, Lederman R, Wadley G, Murray G, Herrman H, Chambers R, Russon P, Miles C, D'Alfonso S, Thurley M, Chinnery G, Gilbertson T, Eleftheriadis D, Barlow E, Cagliarini D, Toh JW, McAlpine S, Koval P, Bendall S, Jansen JE, Hamilton M, McGorry P, Alvarez-Jimenez M. Moderated online social therapy for depression relapse prevention in young people: pilot study of a 'next generation' online intervention. Early Interv Psychiatry. 2018 Aug;12(4):613-25. doi:10.1111/eip.12354
  45. Love SM, Sanders MR, Turner KMT, Maurange M, Knott T, Prinz R, et al. Social media and gamification in parenting interventions. Child Abuse Negl. 2016;53:95–107. doi:10.1016/j.chiabu.2015.11.006
  46. Szigethy E, Wolfson D, Sinclair-McBride K, Williams K, Jhe G, Lee EH, Bialostozky M, Wallace M, Bhatnagar S, Demaso DR, Yealy DM, Hollenbach K. Efficacy of a digital mental health intervention embedded in routine care compared with treatment as usual in adolescents and young adults with moderate depressive symptoms: protocol for randomised controlled trial. BMJ Open. 2023 Mar 31;13(3):e067141. doi:10.1136/bmjopen-2022-067141
  47. Espinosa V, Valiente RM, García-Escalera J, Chorot P, Sandín B. Transdiagnostic internet-based program for adolescents. Behav Res Ther. 2024;179:104560. doi:10.1016/j.brat.2024.104560
  48. Wang J, Lam RW, Ho K, Attridge M, Lashewicz B, Patten SB, et al. Preferred features of e-mental health programs. J Med Internet Res. 2016;18(6):e132. doi:10.2196/jmir.4802
  49. Werner-Seidler A, Huckvale K, Larsen ME, Calear AL, Maston K, Johnston L, et al. Digital prevention of depression in adolescents. Trials. 2020;21:2. doi:10.1186/s13063-019-3955-6
  50. Woods B, Rai HK, Elliott E, Aguirre E, Orrell M, Spector A. Cognitive stimulation for dementia. Cochrane Database Syst Rev. 2023;1:CD005562. doi:10.1002/14651858.CD005562.pub3
  51. Bulthuis SE, Kok MC, Raven J, Dieleman MA. Scale-up of public health interventions in LMICs. Health Policy Plan. 2020;35(2):219–234. doi:10.1093/heapol/czz140
  52. Kiral IA. Risk identification techniques in construction projects. Buildings. 2025;15(20):3806. doi:10.3390/buildings15203806
  53. Kelders SM, van Zyl LE, Ludden GDS. Engagement in eHealth: a scoping review. Front Psychol. 2020;11:926. doi:10.3389/fpsyg.2020.00926
  54. Berardi C, Antonini M, Jordan Z, Wechtler H, Paolucci F, Hinwood M. Barriers to digital mental health implementation. BMC Health Serv Res. 2024;24:243. doi:10.1186/s12913-023-10536-1
  55. Sharma V, Sharma A. Social media and adolescent mental health. Cureus. 2026;18(2):e103089. doi:10.7759/cureus.103089
  56. Alsalloum G, Dalibalta S, Hadijat Y. Digital health interventions for depression heterogeneity. Front Digit Health. 2025;7:1654745. doi:10.3389/fdgth.2025.1654745

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